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Effect of Ketorolac Tromethamine on Atracurium‐Induced Neuromuscular Blockade in Anesthetized Dogs
Author(s) -
MARTINEZ ELIZABETH A.,
WOOLDRIDGE ANNE A.,
HARTSFIELD SANDEE M.
Publication year - 1997
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1997.tb00527.x
Subject(s) - medicine , anesthesia , isoflurane , ketorolac tromethamine , placebo , blockade , ketorolac , neuromuscular blockade , analgesic , receptor , alternative medicine , pathology
Objective —The purpose of this study was to determine the effect of ketorolac tromethamine or placebo on the neuromuscular blockade induced by an infusion of atracurium in isoflurane‐anesthetized dogs. Design —Randomized, controlled trial. Animals —Six healthy, adult mixed‐breed dogs (five female, one male) weighing 24.8 ± 2.8 kg. Methods —Dogs were studied on two occasions with a minimum of 7 days between studies. Dogs were induced with 5% isoflurane in oxygen and maintained with 1.6 ± minimum alveolar concentration (MAC) end‐tidal isoflurane. Neuromuscular blockade was assessed using the train of‐four response. Once 50% depression of the first twitch (T 1 ) was achieved, the atracurium infusion rate was held constant for 30 minutes. Then ketorolac, 0.5 mg/kg, or the same volume of placebo (0.9% sodium chloride solution) was administered intravenously and the atracurium infusion maintained for an additional 60 minutes. Before and at 2, 5, 10, 15, 30, and 60 minutes after ketorolac or placebo, the percent depression of T 1 and the fourth twitch to the first twitch (T 4 /T 1 ) ratio were recorded. The atracurium infusion was discontinued and the time for T 1 to recover from 50% to 75% of its original value was recorded. At 75% T 1 , edrophonium, 0.5 mg/kg intravenously, was administered to antagonize the residual blockade. Results —There was no significant difference in T 1 %, T 4 /T 1 ratio, or recovery time after ketorolac administration compared with placebo. Conclusions —Ketorolac, 0.5 mg/kg intravenously, has no significant effect on either atracuriuminduced neuromuscular blockade or recovery time for T 1 in isoflurane‐anesthetized dogs. Clinical Relevance —The concurrent use of atracurium should not be a contraindication for the administration of ketorolac for intraoperative or postoperative analgesia.