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Cardiovascular and Pulmonary Effects of Sevoflurane Anesthesia in Horses
Author(s) -
AIDA HIROKO,
MIZUNO YUTAKA,
HOBO SEIJI,
YOSHIDA KOHEI,
FUJINAGA TORU
Publication year - 1996
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1996.tb01393.x
Subject(s) - sevoflurane , medicine , anesthesia , hemodynamics , ventilation (architecture) , cardiac output , anesthetic , stroke volume , heart rate , vascular resistance , respiratory minute volume , minimum alveolar concentration , blood pressure , arterial blood , respiratory system , mechanical engineering , engineering
The effects of 1.0, 1.5, and 2.0 minimum alveolar concentration (MAC) of sevoflurane on hemodynamic, pulmonary and blood chemistry variables were measured during spontaneous and controlled ventilation in healthy horses. Sevoflurane was the only anesthetic drug administered to the horses. In a dose‐dependent manner, sevoflurane significantly decreased ( P <.05) mean arterial blood pressure, cardiac output, and stroke volume. There was a progressive decrease in peripheral vascular resistance and an increase in heart rate as the concentration of sevoflurane was increased, but the differences were not significant. During spontaneous ventilation there was a dose‐dependent decrease in respiratory rate that caused a decrease in the minute volume. As the dose of sevoflurane increased, the arterial carbon dioxide tension also increased ( P <.05). All blood chemistries remained within normal limits. Recovery from anesthesia was without incident. In conclusion, sevoflurane induces a dose‐dependent decrease in hemodynamic variables and pulmonary function in horses that is not greatly different from that of other approved inhalant anesthetics.