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Cephalothin and Cefazolin In Vitro Antibacterial Activity and Pharmacokinetics in Dogs
Author(s) -
PETERSEN STEVEN W.,
ROSIN EBERHARD
Publication year - 1995
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1995.tb01341.x
Subject(s) - cefazolin , medicine , pharmacokinetics , in vitro , pharmacology , antibacterial activity , microbiology and biotechnology , antibiotics , bacteria , biochemistry , biology , genetics
The periods of time that cephalothin and cefazolin serum concentration remained above minimum inhibitory concentration (MIC) for beta hemolytic, coagulase positive staphylococcal, and Escherichia coli clinical isolates were compared. Cephalothin and cefazolin were similarly very effective in vitro against staphylococcal isolates, with an MIC 90 of 0.12 μg/mL and 0.25 μg/mL, respectively. In contrast, cefazolin was more effective than cephalothin against E coli isolates; the cefazolin MIC 90 for E coli was 16 μg/mL and for cephalothin 64 μg/mL. Cefazolin (20 mg/kg intravenously [IV]) serum concentration remained more than MIC 90 for E coli isolates significantly longer than serum concentration of cephalothin (40 mg/kg IV) ( P <.001).