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Determination of the ED50 of Isoflurane and Evaluation of the Isoflurane‐Sparing Effect of Butorphanol in Cockatoos (Cacatua spp.)
Author(s) -
CURRO THOMAS G.,
BRUNSON DAVID B.,
PAULMURPHY JOANNE
Publication year - 1994
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1994.tb00502.x
Subject(s) - butorphanol , medicine , isoflurane , anesthesia , ed50 , receptor
The use of butorphanol as an analgesic in a psittacine species was evaluated by determining its isoflurane‐sparing effects. The Effective Dose 50 (ED50) of isoflurane was determined using a bracketing technique based on the purposeful movement elicited by pressure applied to a digit with a hemostat. The ED50 of isoflurane for 11 cockatoos (four greater sulfur crested, three lesser sulfur crested, and four citron crested) was determined to be 1.44 ± 0.07%. After the administration of 1 mg/kg of butorphanol tartrate intramuscularly (IM), the ED50 was significantly ( P < .05) decreased to 1.08 ± 0.05%. Physiological variables that changed significantly included decreases in heart rate, tidal volume (V t ), inspiratory (T j ) and expiratory times (T e ), and an increase in respiratory rate. No complications resulted because of these changes. Based on the results, butorphanol produces an isoflurane‐sparing effect in cockatoos and has the potential to be a useful analgesic in psittacines.