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Chemonucleolysis with Collagenase A Radiographic and Pathologic Study in Dogs
Author(s) -
MIYABAYASHI TAKAYOSHI,
LORD PETER F.,
DUBIELZIG RICHARD R.,
BILLER DAVID S.,
MANLEY PAUL A.
Publication year - 1992
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1992.tb00044.x
Subject(s) - medicine , collagenase , radiography , pathology , radiology , enzyme , biochemistry , chemistry
Collagenase, a proteolytic enzyme, was injected intradiscally in nine clinically normal, middle‐aged beagles. Calcium chloride diluent solution (control), 100 ABC units of collagenase, and 250 ABC units of collagenase, were injected in randomly selected intervertebral discs (T13‐L1 to L5‐L6). On day 11, the discs injected with collagenase were narrowed radiographically, but there was no significant change in myelograms. Grossly and histologically, there was dissolution of the intervertebral discs, mainly nucleus pulposus, and protrusion of nucleus material in the vertebral body through bony end‐plates in discs injected with collagenase. Collagenase chemonucleolysis may be an alternative to spinal surgery for intervertebral disc protrusion in dogs.