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Effects of Four Preparations of 0.05% Chlorhexidine Diacetate on Wound Healing in Dogs
Author(s) -
LOZIER SCOTT,
POPE ERIC,
BERG JOHN
Publication year - 1992
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1992.tb00025.x
Subject(s) - antiseptic , chlorhexidine , medicine , wound healing , in vivo , staphylococcus aureus , microbiology and biotechnology , dentistry , surgery , bacteria , pathology , biology , genetics
Four chlorhexidine diacetate (CHD) antiseptic wound lavage preparations were evaluated in vivo to determine their effects on second intention wound healing in the dog and in vitro to determine their relative antibacterial activity against Staphylococcus intermedius. Chlorhexidine was diluted to 0.05% in sterile water, 0.9% sodium chloride, lactated Ringers solution (LRS), and LRS that was allowed to form a precipitate with CHD. Control solutions included sterile water and LRS. There were no significant differences in wound contraction or epithelialization. Ail 0.05% CHD preparations provided 100% bacterial kill.