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Pharmacokinetic Disposition of Cefazolin in Serum and Tissue during Canine Total Hip Replacement
Author(s) -
RICHARDSON DANIEL C.,
AUCOIN DAVID P.,
DEYOUNG DAVID J.,
TYCZKOWSKA KRYSTYNA L.,
DeYOUNG BONNIE A.
Publication year - 1992
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1992.tb00002.x
Subject(s) - cefazolin , medicine , acetabulum , pharmacokinetics , cancellous bone , femur , surgery , antibiotics , biology , microbiology and biotechnology
Intraoperative cefazolin concentrations were measured in serum, joint capsule, cancellous bone of the acetabulum, and proximal cancellous bone of the femur in 15 dogs undergoing total hip replacement. Cefazolin (22 mg/kg intravenously [IV]) was administered every hour for three doses. The mean peak serum concentrations (±SEM) were 387.79 ± 27.56 μg/mL, 521.71 ± 28.00 μg/mL, and 542.20 ± 30.91 μg/mL, respectively. Mean serum concentrations just before administration of doses 2 and 3 were 51.77 ± 2.39 μg/mL, and 64.84 ± 3.46 μg/mL, respectively. The mean cefazolin concentrations in the joint capsule, cancellous bone of the acetabulum, and cancellous bone of the femur were 34.71 ± 2.50 μg/g, 28.70 ± 7.40 μg/g, and 36.20 ± 3.80 μg/g, respectively. The minimum inhibitory concentration of cefazolin for 90% of the common contaminants (MIC 90 ) in this clinic is ≤ 2 μg/mL or per gram of tissue. Serum concentrations never fell below 15 times the MIC 90 (lowest trough, 35.93 μg/mL), and the lowest tissue concentration (6.57 μg/mL in cancellous bone from the acetabulum) was still more than 3 times the MIC 90 . The mean tissue concentration was 15 times the MIC 90 .