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Treatment of Low Arterial Oxygen Tension in Anesthetized Horses with Clenbuterol
Author(s) -
KEEGAN R. D.,
GLEED R. D.,
SANDERS E. A.,
SEAMAN G. C.,
WERTZ E. M.,
SHORT C. E.
Publication year - 1991
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1991.tb00325.x
Subject(s) - clenbuterol , medicine , arterial oxygen tension , anesthesia , inhalation , ventilation (architecture) , oxygen tension , oxygen , lung , mechanical engineering , chemistry , organic chemistry , engineering
Clenbuterol (0.8 4mUg/kg intravenously) was administered to 10 anesthetized horses with an abnormally low Pao 2 (<90 mm Hg) despite controlled ventilation with an oxygen‐rich gas mixture. Results were compared with those from 10 controls to which no clenbuterol was given and in which conventional methods to increase Pao 2 were ongoing. Horses treated with clenbuterol had higher Pao 2 values for at least 90 minutes. Clenbuterol was associated with increased heart rate and profuse sweating. Clenbuterol can be administered intravenously to increase the Pao 2 of mechanically ventilated horses that have low arterial oxygen tension while under inhalation anesthesia. Further studies are warranted to define more precisely the circumstances under which clenbuterol may be used safely.