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Ureterocolonlc Anastomosis in Ten Dogs with Transitional Cell Carcinoma
Author(s) -
STONE ELIZABETH ARNOLD,
WITHROW STEPHEN J.,
PAGE RODNEY L.,
SCHWARZ PETER D.,
WHEELER STEVEN L.,
III HOWARD B. SEIM
Publication year - 1988
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.1988.tb00293.x
Subject(s) - medicine , metabolic acidosis , vomiting , transitional cell carcinoma , surgery , uremia , hyperammonemia , anastomosis , blood urea nitrogen , creatinine , anesthesia , bladder cancer , cancer
Ureterocolonic anastomosis (UCA) was performed in 10 dogs with transitional cell carcinoma of the urinary bladder trigone or the urethra, or both. All grossly visible tumor was excised. All of the dogs recovered from anesthesia and surgery and had anal continence with no urine leakage. One dog died of undetermined causes 7 days after surgery. Nine dogs survived 1 to 5 months. The owners of eight of the dogs considered their dog's quality of life to be acceptable. Four dogs were euthanatized because of neurologic disease, three of which also had nausea and vomiting. The neurologic and gastrointestinal signs may have been caused by hyperammonemia, metabolic acidosis, and uremia. Blood ammonia levels were elevated in two dogs with neurologic signs. Hyperchloremic metabolic acidosis that was reversible with bicarbonate therapy was diagnosed in five dogs. All of the dogs were azotemic because of intestinal recycling of urea. Serum creatinine concentrations increased in four dogs after surgery. Drug‐induced renal disease may have developed in two dogs. Pyelonephritis developed in five kidneys, two of which had outflow obstruction and two had bilateral hydrouretero‐nephrosis before the UCA. In this small number of dogs, surgical excision of transitional cell carcinoma was not curative with six dogs having confirmed metastatic lesions at the time of death.