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Pilot Randomized Controlled Dosing Study of Cranberry Capsules for Reduction of Bacteriuria Plus Pyuria in Female Nursing Home Residents
Author(s) -
Bianco Luann,
Perrelli Eleanor,
Towle Virginia,
Ness Peter H.,
JuthaniMehta Manisha
Publication year - 2012
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2012.03976.x
Subject(s) - medicine , pyuria , bacteriuria , nursing homes , dosing , randomized controlled trial , nursing , urine
Cranberry products represent a non-antimicrobial method for prevention of urinary tract infection (UTI). Cranberry proanthocyanidin (PAC), a type of condensed tannin, is the active ingredient in cranberry that inhibits adherence of P-fimbriated Escherichia coli (E.coli) to uroepithelial cells.1, 2 Previous cranberry studies for UTI prevention yielded conflicting results, likely because of variability of PAC dose and clinical populations studied.3, 4 In a clinical trial of 300ml of cranberry juice beverage daily (36mg PAC), older women (mean age 78.5 years) had a 58% reduction in the odds of having bacteriuria plus pyuria compared to controls.5 However, nursing home residents have difficulty ingesting the volume of juice that is necessary to prevent bacteriuria. Cranberry capsules are feasible to administer to nursing home residents, but their efficacy has not been demonstrated.6 In vitro, 36 to 108mg of PAC is efficacious at inhibiting bacterial adherence to uroepithelial cells,7 but the most efficacious dose among older nursing home residents has not been identified. The goal of this study was to identify the optimal dose of cranberry capsules that reduced the incidence of bacteriuria plus pyuria over one month.