Premium
Nocturnal Hypokinesia and Sleep Quality in Parkinson's Disease
Author(s) -
Louter Maartje,
Munneke Marten,
Bloem Bastiaan R.,
Overeem Sebastiaan
Publication year - 2012
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2012.03966.x
Subject(s) - hypokinesia , medicine , nocturnal , physical therapy , pediatrics
Objectives To study the relationship between nocturnal hypokinesia and sleep quality in Parkinson's disease ( PD ). Design Questionnaire study using intergroup analysis. Setting P arkinson C entre N ijmegen, a tertiary university referral center. Participants Two hundred forty individuals with P arkinson's disease. Measurements Clinical and demographic data were obtained. Nocturnal hypokinesia was assessed using Question 35 of the P arkinson's D isease Q uality of L ife Q uestionnaire and rated on a 5‐point Likert scale (1 = all of the time to 5 = never). The P ittsburgh S leep Q uality I ndex ( PSQI ) was used to quantify sleep quality, higher scores indicating poorer sleep quality. Results One hundred thirty‐five of 240 participants had difficulties turning over in bed. Mean PSQI scores were significantly higher in participants with nocturnal hypokinesia (7.7 ± 4.1) than in those without (6.1 ± 3.4, P = .001). A regression model correcting for age, disease duration, and H oehn and Y ahr stage showed a significant influence of nocturnal hypokinesia on sleep quality (coefficient of determination = 0.042, standardized‐beta = 0.163, P = .03). There was a linear relationship between frequency of nocturnal hypokinesia and sleep quality. Conclusion This is the first study that documents that nocturnal hypokinesia negatively affects sleep quality in PD . Nocturnal hypokinesia therefore merits therapeutic attention, including optimal nighttime dopaminergic treatment and education about turning strategies in bed.