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Family History of Exceptional Longevity Is Associated with Lower Serum Uric Acid Levels in A shkenazi J ews
Author(s) -
Lai Jennifer YiChun,
Atzmon Gil,
Melamed Michal L.,
Hostetter Thomas H.,
Crandall Jill P.,
Barzilai Nir,
Bitzer Markus
Publication year - 2012
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2012.03902.x
Subject(s) - offspring , medicine , hyperuricemia , renal function , uric acid , kidney disease , longevity , endocrinology , cohort , confidence interval , physiology , gerontology , pregnancy , biology , genetics
Objectives To test whether lower serum uric acid ( UA ) levels are associated with longevity independent of renal function. Design Cross‐sectional cohort study. Setting A shkenazi J ewish individuals with exceptional longevity (Longevity Genes Project at A lbert E instein C ollege of M edicine). Participants Long‐lived individuals ( LLI ) of A shkenazi J ewish ethnicity (mean age ± standard deviation 97.7 ± 2.9, n = 365), their offspring (mean age ± standard deviation 68.2 ± 8.2, n = 593) and controls (without family history of longevity, mean age ± standard deviation 72.5 ± 9.9, n = 356). Measurements Association between UA levels and estimated glomerular filtration rate ( eGFR ) as well as chronic kidney disease ( CKD ) stage, and correlation of UA levels of LLI and offspring were determined. Because LLI lack an appropriate control group, UA levels, eGFR , and prevalence of hyperuricemia and CKD stages were compared between offspring and controls. Results Offspring were less likely to have hyperuricemia and had lower UA levels than controls. Despite negative correlation between UA levels and eGFR and positive correlation between UA levels and CKD stages, eGFR and the prevalence of CKD stage III to V were not found to be different between offspring and controls. Furthermore, significant association between UA levels in LLI and their offspring (β estimate 0.1544, 95% confidence interval = 0.08–0.23, P < .001) has been observed. Conclusion Offspring had lower UA levels than controls despite similar renal function, suggesting that other factors such as UA metabolism or renal tubular transport determine UA levels. The association between UA levels and longevity is particularly intriguing because UA levels are potentially modifiable with diet and drugs.