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Serum 25‐Hydroxyvitamin D and Physical Function in Older Adults: The Cardiovascular Health Study All Stars
Author(s) -
Houston Denise K.,
Tooze Janet A.,
Davis Cralen C.,
Chaves Paulo H. M.,
Hirsch Calvin H.,
Robbins John A.,
Arnold Alice M.,
Newman Anne B.,
Kritchevsky Stephen B.
Publication year - 2011
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2011.03601.x
Subject(s) - medicine , vitamin d and neurology , confidence interval , grip strength , gerontology , physical therapy , demography , sociology
Objectives To examine the association between 25‐hydroxyvitamin D (25( OH ) D ) and physical function in adults of advanced age. Design Cross‐sectional and longitudinal analysis of physical function over 3 years of follow‐up in the Cardiovascular Health Study All Stars. Setting F orsyth County, N orth C arolina; S acramento County, C alifornia; W ashington County, M aryland; and A llegheny County, P ennsylvania. Participants Community‐dwelling adults aged 77 to 100 (N = 988). Measurements Serum 25‐hydroxyvitamin D 25( OH ) D ), Short Physical Performance Battery ( SPPB ), and grip and knee extensor strength assessed at baseline. Mobility disability (difficulty walking half a mile or up 10 steps) and activities of daily living ( ADL s) disability were assessed at baseline and every 6 months over 3 years of follow‐up. Results Almost one‐third (30.8%) of participants were deficient in 25( OH ) D (<20 ng/mL). SPPB scores were lower in those with deficient 25( OH ) D (mean (standard error) 6.53 (0.24)) than in those with sufficient 25( OH ) D (≥30 ng/mL) (7.15 (0.25)) after adjusting for sociodemographic characteristics, season, health behaviors, and chronic conditions ( P = .006). Grip strength adjusted for body size was also lower in those with deficient 25( OH ) D than in those with sufficient 25(OH)D (24.7 (0.6) kg vs 26.0 (0.6) kg, P = .02). Participants with deficient 25( OH ) D were more likely to have prevalent mobility ( OR = 1.44, 95% confidence interval ( CI )) = 0.96–2.14) and ADL disability ( OR = 1.51, 95% CI = 1.01–2.25) at baseline than those with sufficient 25( OH ) D . Furthermore, participants with deficient 25( OH ) D were at greater risk of incident mobility disability over 3 years of follow‐up (hazard ratio = 1.56, 95% CI = 1.06–2.30). Conclusion Vitamin D deficiency was common and was associated with poorer physical performance, lower muscle strength, and prevalent mobility and ADL disability in community‐dwelling older adults. Moreover, vitamin D deficiency predicted incident mobility disability.