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Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults
Author(s) -
Finkle William D.,
Der Jane S.,
Greenland Sander,
Adams John L.,
Ridgeway Gregory,
Blaschke Terrance,
Wang Zixia,
Dell Richard M.,
VanRiper Kurt B.
Publication year - 2011
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2011.03591.x
Subject(s) - zolpidem , alprazolam , medicine , lorazepam , confidence interval , diazepam , benzodiazepine , medical prescription , relative risk , anesthesia , confounding , psychiatry , pharmacology , anxiety , insomnia , receptor
Objectives To determine whether zolpidem is a safer alternative to benzodiazepines. Design Retrospective cohort study. Setting Community based. Participants Health maintenance organization members with an initial prescription for zolpidem (n = 43,343), alprazolam (n = 103,790), lorazepam (n = 150,858), or diazepam (n = 93,618). Measurements Zolpidem and benzodiazepine prescriptions were identified from pharmacy databases. Rates of nonvertebral fractures and hip fractures requiring hospitalization were compared before and after an initial prescription for each treatment, adjusting for confounders using doubly robust estimation. Results In patients aged 65 and older, the rates of nonvertebral fractures and dislocations were similar in the pre‐ treatment intervals. The rate ratios ( RR s) for the 90‐day posttreatment interval relative to the pretreatment interval were 2.55 (95% confidence interval ( CI ) = 1.78–3.65; P < .001) for zolpidem, 1.14 (95% CI = 0.80–1.64; P = .42) for alprazolam, 1.53 (95% CI = 1.23–1.91; P < .001) for lorazepam, and 1.97 (95% CI = 1.22–3.18; P = .01) for diazepam. The ratio of RR s ( RRR )—the RR in the posttreatment period adjusted for the corresponding RR in the pretreatment period—were 2.23 (95% CI = 1.36–3.66; P = .006) for zolpidem relative to alprazolam, 1.68 (95% CI = 1.12–2.53; P = .02) for zolpidem relative to lorazepam, and 1.29 (95% CI = 0.72–2.30; P = .32) for zolpidem relative to diazepam. The RR s decreased with time from the initial prescription (trend P < .001), as would be expected if the association is causal. Conclusion In older adults, the risk of injury with zolpidem exceeded that with alprazolam and lorazepam and was similar to that with diazepam. If the associations are causal, then the high incidence of these fractures implies that these treatment induce a substantial number of fractures and consequential costs. Further study of the association is imperative.