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Adiponectin Isoforms in Elderly Patients with or without Coronary Artery Disease
Author(s) -
Rizza Stefano,
Gigli Fabrizio,
Galli Angelica,
Micchelini Barbara,
Lauro Davide,
Lauro Renato,
Federici Massimo
Publication year - 2010
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2010.02773.x
Subject(s) - medicine , adiponectin , coronary artery disease , diabetes mellitus , myocardial infarction , waist , cardiology , ambulatory , endocrinology , body mass index , insulin resistance
OBJECTIVES: To study the distribution of adiponectin isoforms in a group of very old patients. DESIGN: Cross‐sectional. SETTING: Geriatric ambulatory clinic of the Department of Medicine at Policlinico “Tor Vergata.” PARTICIPANTS: One hundred eight elderly adults (mean age 85.0±3.2) with or without a history of a previous myocardial infarction as proof of established coronary artery disease (CAD) at least 3 months before entry into the study. Accordingly, subjects were divided into CAD positive (CAD+, n=50) and CAD negative (CAD−, n=58). MEASUREMENT: Assessment of adiponectin isoforms along with metabolic, lipid, and inflammatory profiles. RESULTS: CAD+ subjects had significantly higher levels of total adiponectin (Tot‐Ad) and low‐molecular‐weight adiponectin (LMW‐Ad) than CAD− subjects ( P= .008 for both). LMW‐Ad and high‐sensitivity C‐reactive protein were positively correlated, even after adjustment for waist circumference, sex, glomerular filtration rate, and presence of diabetes mellitus (correlation coefficient ( r )=0.25, P =.05). This association was not confirmed when CAD+ subjects were analyzed alone. A positive association was found in CAD+ subjects between brain natriuretic peptide (BNP), high‐molecular‐weight adiponectin (HMW‐Ad), and Tot‐Ad ( r =0.798 and r =0.795, P <.001 for all) but not LMW‐Ad. CONCLUSION: Distribution of adiponectin isoforms differed in populations of elderly subjects according to the presence of coronary atherosclerosis. The data support the hypothesis for a protective role of LMW‐Ad during aging, although additional studies are needed to definitively clarify whether LMW‐Ad plays a protective role in older people with a history of CAD.