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COMPARING INDEXES OF FRAILTY: THE CARDIOVASCULAR HEALTH STUDY AND THE STUDY OF OSTEOPOROTIC FRACTURES
Author(s) -
Filho Sergio Telles Ribeiro,
Lourenço Roberto Alves,
Moreira Virgilio Garcia
Publication year - 2010
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2009.02690.x
Subject(s) - medicine , index (typography) , population , gerontology , cardiovascular health , table (database) , physical therapy , disease , pathology , data mining , environmental health , computer science , world wide web
intravenous bisphosphonate treatment, although this did not translate into detectable improvements in rehabilitation outcomes, which may have been because of insufficient responsiveness of these outcome measures and possibly because of the small doses of vitamin D supplemented and short duration of the study. With regard to the optimal dosage of vitamin D after hip fracture, a daily oral vitamin D replacement was shown to be more effective in improving 25OHD levels after 1 year than 300,000 IU D2 intramuscularly once yearly, suggesting the benefits of ongoing vitamin D supplementation. According to the results of the current study, we would advocate a vitamin D replacement protocol similar to that of a previous study, consisting of an initial parenteral loading dose (50,000–125,000 IU intramuscularly) within 10 days of hip fracture, followed by daily oral vitamin D (800–1,200 IU) and calcium (1,000– 1,500 mg daily). We would also advocate for a large-dose parenteral vitamin D formation to be made available in Australia, because this is not currently available. Further studies are required to ascertain whether a larger initial loading dose of parenteral vitamin D can translate into improvements in rehabilitation outcomes.