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Brain‐Derived Neurotrophic Factor Predicts Mortality Risk in Older Women
Author(s) -
Krabbe Karen S.,
Mortensen Erik L.,
Avlund Kirsten,
Pedersen Agnes N.,
Pedersen Bente K.,
Jørgensen Torben,
Bruunsgaard Helle
Publication year - 2009
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2009.02345.x
Subject(s) - medicine , hazard ratio , cohort , proportional hazards model , brain derived neurotrophic factor , cohort study , risk factor , population , neurotrophic factors , disease , biomarker , confidence interval , oncology , environmental health , biochemistry , chemistry , receptor
OBJECTIVES: To test the hypothesis that low circulating brain‐derived neurotrophic factor (BDNF), a secretory member of the neurotrophin family that has a protective role in neurodegeneration and stress responses and a regulatory role in metabolism, predicts risk of all‐cause mortality in 85‐year‐old men and women. DESIGN: Longitudinal study with 50‐ to 58‐month follow‐up. SETTING: The 1914 cohort, a population‐based cohort established in 1964 by the Research Center for Prevention and Health at Glostrup Hospital. PARTICIPANTS: One hundred eighty‐eight unselected 85‐year‐old Danes. MEASUREMENTS: BDNF was measured in plasma and serum. The Danish National Register of Patients was used to collect data on morbidity. The primary outcome in Cox regression analyses was all‐cause mortality. RESULTS: Women with low plasma BDNF (lowest tertile) had greater all‐cause mortality risk than women with high plasma BDNF (highest tertile) (hazard ratio=2.2, 95% confidence interval=1.1–4.7). Low plasma BDNF predicted mortality independently of activities of daily living; education; and a history of central nervous system disease, cerebrovascular accidents, cardiovascular disease, cancer, respiratory disease, and low‐grade inflammation. No association was found between plasma BDNF and mortality in men, and serum BDNF did not influence mortality in either sex. CONCLUSION: Low plasma BDNF is a novel, independent, and robust biomarker of mortality risk in old women. BDNF may be a central factor in the network of multimorbidity in old populations.