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Rapid Screening of Cognitive Change in Patients with Questionable Dementia Using the Memory Impairment Screen and the Isaacs Set Test
Author(s) -
Chopard Gilles,
Vanholsbeeck Geraldine,
Tio Gregory,
Pitard Alexandre,
Binetruy Mickael,
Rumbach Lucien,
Galmiche Jean
Publication year - 2009
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2008.02170.x
Subject(s) - medicine , dementia , cognitive impairment , test (biology) , cognition , set (abstract data type) , memory clinic , memory impairment , screening test , cognitive test , gerontology , psychiatry , audiology , pediatrics , disease , paleontology , computer science , biology , programming language
OBJECTIVES: To assess the efficacy of combining the Memory Impairment Screen (MIS) and the Isaacs Set Test (IST) in predicting short‐term development of dementia in a group of people with questionable dementia (QD) at baseline. DESIGN: Performances of the weighted sum of MIS and IST and the ≪or≫ rule were compared with each other and with the Mini‐Mental State Examination. SETTING: Database of the Regional Network for Diagnostic Aid and Management of Patients with Cognitive Impairment in the Franche‐Comté geographical area in France. PARTICIPANTS: A cohort of 106 patients aged 65 and older with QD were followed up for a mean of 14.9 months (range 6–24 months). MEASUREMENTS: Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for the combination of these two tests. RESULTS: The weighted sum had a sensitivity of 0.74 and a specificity of 0.84. The ≪or≫ rule (MIS<6 or IST<25) had a sensitivity of 0.74 and a specificity of 0.81. When range values were applied, low scores on the MIS and the IST (MIS<6 and IST<25) led to a high probability of dementia, whereas high scores (MIS>7 and IST>29) suggested a high probability of remaining dementia‐free in the study follow‐up. CONCLUSION: This quickly performed tool (5 minutes) is simple to use and score. When including cutscores (MIS<6 or IST<25) or range values, this test could be considered a useful screening procedure for all types of dementias.