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Muscle Endurance in Elderly Nursing Home Residents Is Related to Fatigue Perception, Mobility, and Circulating Tumor Necrosis Factor‐Alpha, Interleukin‐6, and Heat Shock Protein 70
Author(s) -
Bautmans Ivan,
Njemini Rose,
Predom Heidi,
Lemper JeanClaude,
Mets Tony
Publication year - 2008
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2007.01571.x
Subject(s) - medicine , shock (circulatory) , physical therapy , gerontology
OBJECTIVES: To explore the relationships between muscle endurance and circulating interleukin (IL)‐6, tumor necrosis factor alpha (TNF‐α), and heat shock protein (Hsp)70 in nursing home residents and to assess how muscle endurance relates to self‐perceived fatigue and mobility. DESIGN: Exploratory study. SETTING: Three nursing homes of the Foundation for Psychogeriatrics (Brussels, Belgium). PARTICIPANTS: Seventy‐seven residents (53 female and 24 male, mean age 81 ± 8). MEASUREMENTS: Participants were assessed for muscle endurance (fatigue resistance and grip work); perceived fatigue (visual analogue scale for fatigue); fatigue during daily activities (Mobility‐Tiredness Scale); effect of fatigue on quality of life (World Health Organization Quality Of Life questionnaire); mobility (Tinetti Test & Elderly Mobility Scale (EMS)); and circulating IL‐6, TNF‐α, and Hsp70. RESULTS: Residents with better fatigue resistance reported less self‐perceived tiredness ( P <.05). Similar trends were observed for fatigue during daily activities and for the extent to which fatigue bothered subjects. Higher grip work was associated with less self‐perceived fatigue on all fatigue scales ( P <.01). Fatigue resistance and grip work were positively related to balance and basic mobility (all P <.01; trend for relationship between fatigue resistance and EMS). Subjects with high IL‐6 and Hsp70 showed significantly worse fatigue resistance ( P =.007) and muscle work ( P =.045) than those with high IL‐6 and low Hsp70. In male residents, higher TNF‐α was related to worse fatigue resistance and grip work ( P <.05). CONCLUSION: Elderly nursing home residents complaining of fatigue need to be taken seriously, because they show worse muscle endurance, which is related to poorer mobility. Inflammatory processes involving TNF‐α and the interaction between IL‐6 and Hsp70 are related to poorer muscle endurance in these patients.

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