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Diagnosing and Treating Breast Cancer in Elderly Women: A Call for Improved Understanding
Author(s) -
Downey Leona,
Livingston Robert,
Stopeck Alison
Publication year - 2007
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2007.01369.x
Subject(s) - medicine , breast cancer , malignancy , incidence (geometry) , cancer , hormone therapy , intensive care medicine , population , hormonal therapy , adjuvant chemotherapy , chemotherapy , geriatric oncology , oncology , physics , environmental health , optics
Breast cancer is the most common nondermatological malignancy in women, and the incidence increases with age until the eighth decade. Breast cancer pathology and biology appear to be different in elderly patients than in younger ones, and therefore treatment recommendations cannot be generalized from one group to the other. Most elderly women can tolerate breast cancer surgery without significant complications and should be offered a definitive surgical procedure. Improved mechanisms to predict which patients will tolerate and benefit from various therapies are under development. Because most breast cancers in the elderly are hormone responsive, hormonal therapy remains the mainstay of systemic treatment in the adjuvant and metastatic settings. Chemotherapy can be used in elderly women, but treatment decisions must be individualized based upon risk–benefit analyses. Elder‐specific studies are underway to identify the most‐efficacious and best‐tolerated therapies for breast cancer in this population. Primary care physicians must be aware of these issues to provide adequate counseling and care to these patients.