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What's New in Stroke? The Top 10 for 2004/05
Author(s) -
Tonarelli Silvina B.,
Hart Robert G.
Publication year - 2006
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2006.00666.x
Subject(s) - medicine , stroke (engine) , atrial fibrillation , clinical trial , intracerebral hemorrhage , randomized controlled trial , cohort , acute stroke , disease , intensive care medicine , emergency medicine , physical therapy , subarachnoid hemorrhage , mechanical engineering , tissue plasminogen activator , engineering
During the past decade, stroke has emerged from the dark ages of therapeutic nihilism to the current dawn of treatment activism, fueled by an unprecedented amount of high‐quality clinical research. Here, the choices for the “Top 10” studies of 2004/05 influencing the management of patients with stroke and threatened stroke are reviewed. Nine are randomized, clinical trials involving a total of 61,810 participants. Three studies involved intracerebral hemorrhage, an important stroke subtype in which few trials have previously been carried out. Three studies involved acute treatment of stroke, and their results emphasize that “time is brain,” and minutes count, in management of acute ischemic and hemorrhagic stroke. The 10th study was a longitudinal cohort analysis of participants with atrial fibrillation pooled from six clinical trials that validated predictive schemes to identify those who benefit most from anticoagulation. The practical management implications of these studies refine and improve care of geriatric patients with cerebrovascular disease.