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Interleukin‐6 Modulates Plasma Cholesterol and C‐Reactive Protein Concentrations in Nonagenarians
Author(s) -
Lehtimäki Terho,
Ojala Petri,
Rontu Riikka,
Goebeler Sirkka,
Karhunen Pekka J.,
Jylhä Marja,
Mattila Kari,
Metso Saara,
Jokela Hannu,
Nikkilä Matti,
Wuolijoki Erkki,
Hervonen Antti,
Hurme Mikko
Publication year - 2005
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2005.53484.x
Subject(s) - medicine , quartile , cholesterol , c reactive protein , cohort , endocrinology , plasma levels , population , gastroenterology , inflammation , confidence interval , environmental health
Objectives: To establish whether the relationship between interleukin‐6 (IL‐6) and plasma lipid and C‐reactive protein (CRP) concentrations is different in Finnish nonagenarians than in middle‐aged subjects with lower inflammatory status. Design: Cross‐sectional. Setting: Observational cohort study concentrating on the oldest old. Participants: Nonagenarians (n=291, mean age±standard deviation 90±1; 68 men, 223 women) who lived in the Tampere municipality in southern Finland and a middle‐aged control population from the same area (n=227, aged 44±8). Measurements: Plasma high sensitive CRP and lipid concentrations were analyzed using an automatic analyzer and IL‐6 levels using enzyme‐linked immunosorbent assay. Results: Plasma concentrations of IL‐6 (4.39±5.25 vs 1.88±1.98 pg/mL) and CRP (3.54±4.98 vs 1.53±1.91 mg/L) were significantly higher in nonagenarians than in middle‐aged subjects ( P< .001). In nonagenarians, plasma CRP levels increased ( P< .001) and plasma total cholesterol ( P= .006), low‐density lipoprotein cholesterol ( P= .02), and high‐density lipoprotein cholesterol ( P= .002) levels decreased according to IL‐6 quartiles. In middle‐aged subjects, similar associations were not found. Conclusion: The relationship between IL‐6 and plasma CRP and cholesterol levels in nonagenarians with enhanced systemic inflammation differs from that of middle‐aged subjects.