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Should Older People in Residential Care Receive Vitamin D to Prevent Falls? Results of a Randomized Trial
Author(s) -
Flicker Leon,
MacInnis Robert J.,
Stein Mark S.,
Scherer Sam C.,
Mead Kate E.,
Nowson Caryl A.,
Thomas Jenny,
Lowndes Chris,
Hopper John L.,
Wark John D.
Publication year - 2005
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.2005.00468.x
Subject(s) - medicine , placebo , odds ratio , vitamin d and neurology , confidence interval , randomized controlled trial , rate ratio , incidence (geometry) , physical therapy , physics , alternative medicine , pathology , optics
Objectives: To determine whether vitamin D supplementation can reduce the incidence of falls and fractures in older people in residential care who are not classically vitamin D deficient. Design: Randomized, placebo‐controlled double‐blind, trial of 2 years' duration. Setting: Multicenter study in 60 hostels (assisted living facilities) and 89 nursing homes across Australia. Participants: Six hundred twenty‐five residents (mean age 83.4) with serum 25‐hydroxyvitamin D levels between 25 and 90 nmol/L. Intervention: Vitamin D supplementation (ergocalciferol, initially 10,000 IU given once weekly and then 1,000 IU daily) or placebo for 2 years. All subjects received 600 mg of elemental calcium daily as calcium carbonate. Measurements: Falls and fractures recorded prospectively in study diaries by care staff. Results: The vitamin D and placebo groups had similar baseline characteristics. In intention‐to‐treat analysis, the incident rate ratio for falling was 0.73 (95% confidence interval (CI)=0.57–0.95). The odds ratio for ever falling was 0.82 (95% CI=0.59–1.12) and for ever fracturing was 0.69 (95% CI=0.40–1.18). An a priori subgroup analysis of subjects who took at least half the prescribed capsules (n=540), demonstrated an incident rate ratio for falls of 0.63 (95% CI=0.48–0.82), an odds ratio (OR) for ever falling of 0.70 (95% CI=0.50–0.99), and an OR for ever fracturing of 0.68 (95% CI=0.38–1.22). Conclusion: Older people in residential care can reduce their incidence of falls if they take a vitamin D supplement for 2 years even if they are not initially classically vitamin D deficient.