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Insulin‐like Growth Factor 1 and Functional Status in Healthy Older Men
Author(s) -
Papadakis Maxine A.,
Grady Deborah,
Tierney Mary Jo,
Black Dennis,
Wells Lauren,
Grunfeld Carl
Publication year - 1995
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1995.tb06613.x
Subject(s) - medicine , univariate analysis , ambulatory , gerontology , veterans affairs , timed up and go test , cross sectional study , geriatrics , physical therapy , multivariate analysis , balance (ability) , pathology , psychiatry
OBJECTIVE: To determine if insulin‐like growth factor 1 (IGF‐1) is associated with strength and functional ability in healthy older men. DESIGN: Cross‐sectional study. SETTING: San Francisco Department of Veterans Affairs Medical Center. PARTICIPANTS: One hundred four ambulatory community‐dwelling men. MEASUREMENTS: Serum IGF‐1 levels were obtained. Measured variables included strength of the knee flexors and extensors, handgrip, score on the Physical Performance Test, body composition, and three tests of cognitive function. RESULTS: The subjects' mean age was 75.5±4.9 (SD) years (range 70–94 years), and their mean IGF‐1 level was 134.7±43.6 ng/mL. The univariate association of age with the variables was much stronger than the univariate association of IGF‐1 with the same variables. In multivariable models, age, but not IGF‐1, was associated with the variables. CONCLUSION: In this study of healthy older men, age is the most important variable in predicting functional decline. There was no association of IGF‐1 levels to functional status independent of age. J Am Geriatr Soc 43:1350–1355,1995.