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Metabolic and Behavioral Covariates of High‐Density Lipoprotein Cholesterol and Triglyceride Concentrations in Postmenopausal Women
Author(s) -
Laws Ami,
King Abby C.,
Haskell Williain L.,
MD Gerald M. Reaven
Publication year - 1993
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1993.tb06477.x
Subject(s) - medicine , triglyceride , body mass index , endocrinology , waist–hip ratio , waist , obesity , abdominal obesity , high density lipoprotein , cholesterol
Objective : To determine predictors of high‐density lipoprotein cholesterol (HDL) and triglyceride (TG) concentrations in postmenopausal women. Design : Cross‐sectional study. Setting : Clinical research facility. Participants : One hundred twenty‐seven healthy, relatively sedentary, postmenopausal women not on estrogen replacement, mean age 57 years. Measurements : Alcohol intake, cigarette smoking, aerobic fitness (VO 2 max), body mass index (BMI), percent body fat, waist‐hip ratio, lipids and lipoproteins, fasting plasma glucose (FPG), and insulin (FPI) concentrations. Results : In univariate analyses, HDL was significantly ( P < 0.05) inversely related to BMI, waist‐hip ratio, smoking, FPG, and FPI, and directly related to VO 2 max and alcohpl intake. Triglycerides were related directly to BMI, waist‐hip ratio, percent body fat, FPG, and FPI, and inversely to VO 2 max. In stepwise multiple regressions, BMI, waist‐hip ratio, alcohol, smoking, and FPG were significantly associated with HDL ( R 2 for the model = 0.43). Addition of TG to these models reduced relations of BMI and waist‐hip ratio, but not the other variables, to insignificance. For triglycerides, waist‐hip ratio, alcohol, smoking, FPG, and FPI were significant predictors ( R 2 = 0.33). VO 2 max and percent body fat did not contribute to any model. Conclusions : Obesity, abdominal obesity, smoking, alcohol intake, and measures of carbohydrate metabolism predict HDL and triglyceride concentrations in postmenopausal women.