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Positron Emission Tomography and Familial Alzheimer's Disease: A Pilot Study
Author(s) -
Guze Barry H.,
Hoffman John M.,
Mazziotta John C.,
Baxter Lewis R.,
Phelps Michael E.
Publication year - 1992
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1992.tb01930.x
Subject(s) - medicine , positron emission tomography , alzheimer's disease , disease , ambulatory , fluorodeoxyglucose , pediatrics , nuclear medicine
Objective Local cerebral metabolic rates for glucose were compared between patients with familial Alzheimer's disease (FAD), sporadic Alzheimer's Disease (SAD), and normal controls (NC) to determine if FAD is associated with a unique pattern of brain metabolism. Design Case‐control study matched to convenience sample of FAD. Methods Subjects in the three diagnostic groups were scanned using fluorodeoxyglucose and the Positron Emission Tomographic (PET) technique. The criterion standard of a detailed clinical history and examination were compared to scan results. Setting Patients in a university hospital. Subjects Ambulatory controls and Alzheimer's patients, both sporadic ( n = 8) and familial ( n = 7). The two groups were similar in severity of cognitive dysfunction. Results FAD and SAD patients did not significantly differ in terms of local cerebral metabolic rates for glucose.