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Increased Serum Conjugated Dienes in Elderly Diabetic Patients
Author(s) -
Mooradian Arshag D.
Publication year - 1991
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1991.tb03595.x
Subject(s) - medicine , triglyceride , diabetes mellitus , endocrinology , lipid peroxidation , nephropathy , peripheral neuropathy , cholesterol , gastroenterology , oxidative stress
To determine if lipid peroxidation by‐products are increased in the serum of elderly diabetic patients, serum concentrations of conjugated dienes were measured in 45 Type 2 diabetic men over the age of 60 years, and the results were compared to those of 24 age‐matched healthy men. Patients with diabetic complications such as retinopathy, nephropathy, neuropathy, peripheral vascular disease, coronary or cerebrovascular disease, (n = 22) had significantly increased serum levels of conjugated dienes (0.4951 ± 0.065 O.D./mL) compared to healthy controls (0.2368 ± 0.028 O.D./mL) (P < 0.01). The level of conjugated dienes in diabetic patients without complications (0.3854 ± 0.0316 O.D./mL) was intermediate between the level found in control subjects and the level in patients with diabetic complications. The serum levels of conjugated dienes correlated best with serum triglyceride concentration (r = 0.51) and to a lesser extent with serum glucose concentration (r = 0.36). It is concluded that elderly patients with diabetes, especially those with complications, have increased serum levels of lipid peroxidation by‐products. This can not be totally attributed to alterations in serum cholesterol, phospholipid, or triglyceride levels.