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The Effect of Volume Expansion on Atrial Natriuretic Peptide and Cyclic Guanosine Monophosphate Levels in Young and Aged Subjects
Author(s) -
Tan Adriaan C.I.T.L.,
Hoefnagels Willibrord H.L.,
Swinkels Leon M.J.W.,
Kloppenborg Peter W.C.,
Benraad Theo J.
Publication year - 1990
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1990.tb01502.x
Subject(s) - atrial natriuretic peptide , cyclic guanosine monophosphate , medicine , basal (medicine) , endocrinology , guanosine , plasma renin activity , aldosterone , brain natriuretic peptide , renin–angiotensin system , natriuretic peptide , stimulation , blood pressure , heart failure , chemistry , biochemistry , nitric oxide , insulin
The relationship between atrial natriuretic peptide (ANP) and age was studied. In elderly subjects (65 to 84 years) higher basal ANP levels were found as compared with those found in young subjects (21 to 23 years). Volume loading (750 mL 0.9% NaCl in 60 minutes) increased ANP levels only in the aged group, and plasma renin activity decreased only in the young subjects. Plasma aldosterone levels did not change. Basal cyclic guanosine monophosphate values did not differ in either group, and rose to a similar extent during volume loading. High pressure liquid chromatography analysis did not suggest different molecular forms of immunoreactive ANP in elderly subjects. The main circulating component both basal and after stimulation corresponds to the (99–126)hANP form.