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Foci of Increased T 2 Signal Intensity in MR Images of Healthy Elderly Subjects
Author(s) -
Austrom Mary Guerriero,
Thompson Richard F.,
Hendrie Hugh C.,
Norton James,
Farlow Martin R.,
Edwards Mary K.,
Dean Raymond
Publication year - 1990
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1990.tb01377.x
Subject(s) - medicine , digit symbol substitution test , cognition , intensity (physics) , audiology , effects of sleep deprivation on cognitive performance , mini–mental state examination , cognitive test , gerontology , pathology , psychiatry , cognitive impairment , physics , alternative medicine , quantum mechanics , placebo
An 18‐month follow‐up study was conducted on 26 healthy elderly subjects with and without foci of increased T 2 signal intensity on MR imaging. The subjects did not differ with respect to health status or cognitive performance as measured by the Cognitive Subscale of the Cambridge Mental Disorders of the Elderly Examination and the Mini Mental State Examination at follow‐up. There was a significant decline in performance on the Digit Symbol Substitution Test in subjects who had evidence of T 2 foci compared to the performance of subjects without T 2 foci. This may indicate that the presence of T 2 foci is correlated with subtle difficulties in learning and memory .