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Age‐related Changes in Regional Cerebral Blood Flow and Brain Volume in Healthy Subjects
Author(s) -
Takeda Shumpei,
Matsuzawa Taiju,
Matsui Hiroshige
Publication year - 1988
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1988.tb02353.x
Subject(s) - medicine , cerebral blood flow , arteriosclerosis , age groups , cerebral arteriosclerosis , cardiology , gerontology , demography , sociology
Using the xenon‐133 inhalation method, we studied the age‐related decline in regional cerebral blood flow, calculated as the initial slope index (ISI), in neurologically normal subjects without any risk factors for cerebral arteriosclerosis (154 men and 123 women), ranging in age from 19 to 88 years. The decline in the ISI was rapid in younger age groups and gradual in older age groups. The ISI was higher in women than in men older than 40 years. Using computed tomography, we studied the age‐related decline in brain volume index (BVI; 100% X brain volume/cranial cavity volume) in neurologically normal subjects without any risk factors for cerebral arteriosclerosis (92 men and 49 women), ranging in age from 37 to 86 years. The decline in the BVI was gradual in younger age groups and rapid in older age groups. The BVI was higher in women than in men older than 60 years.