Premium
Clinical Digoxin Toxicity in the Aged in Association With Co‐Administered Verapamil
Author(s) -
Gordon Michael,
Goldenberg Leslie M. C.
Publication year - 1986
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1986.tb04908.x
Subject(s) - digoxin , verapamil , medicine , quinidine , toxicity , pharmacology , pharmacokinetics , drug interaction , calcium channel , concomitant , therapeutic index , calcium , drug , heart failure
Digoxin toxicity occurs more commonly in aged than younger individuals. Cardioactive drugs such as quinidine effect digoxin pharmacokinetics so as to increase the potential for digoxin toxicity. The calcium‐channel antagonists have become extensively used for cardiac disorders and are often co‐administered with digoxin. Despite documented calcium‐channel antagonist interactions with digoxin, clinically significant digoxin toxicity associated with their concurrent use is apparently unusual. Two elderly patients receiving digoxin and verapamil simultaneously are presented to demonstrate the clinical importance and potential danger of the concomitant use of these drugs.