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Renal Effects of Nonsteroidal Antiinflammatory Drugs
Author(s) -
Lamy Peter P.
Publication year - 1986
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1986.tb04319.x
Subject(s) - medicine , activities of daily living , nonsteroidal , population , gerontology , adverse effect , demography , physical therapy , environmental health , sociology
America's population is aging, and there is a direct relationship between advancing age and sensitivity to adverse drug reactions (ADRs). The number of the old old, those 85 years and older, will increase by 114% by the year 2000, and by another 44% in the subsequent 20 years. 1 The largest absolute and relative increases are seen and will continue to be seen for unmarried women older than 85 years (women are more sensitive to ADRs than are men). Importantly, the population 95 years of age and older has increased by about twice the rate of the aggregate population 85 years and older. Activity limitations among community‐living elderly rise precipitously with age, afflicting about 12% of those 65 to 74 years old but almost 46% of those 85 years and older. 2 It has been estimated that approximately 4.6 million community‐living elderly are limited in activities of daily living (ADLs) or instrumental activities of daily living (IADLs, cognitive impairment), 3 and that number may double, triple, or even quadruple in the next 50 years.