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Isolated Systolic Hypertension in the Elderly: A Placebo‐Controlled, Dose‐Response Evaluation of Chlorthalidone
Author(s) -
Morledge John H.,
Ettinger Bruce,
Aranda Juan,
McBarron Frank,
Barra Peter,
Gorwit Jeffrey,
Davidov Michael
Publication year - 1986
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1986.tb04203.x
Subject(s) - chlorthalidone , medicine , placebo , systolic hypertension , isolated systolic hypertension , placebo group , blood pressure , cardiology , anesthesia , alternative medicine , pathology
One hundred seventy‐one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12.5, 25.0, or 50.0 mg or placebo once daily for 12 weeks. The majority of the patients receiving chlorthalidone 12.5 mg achieved therapeutic success with no clinically significant biochemical changes or side effects. The 50.0‐mg dose level enhanced efficacy only minimally over the 25.0‐mg dose level. Drug‐related side effects were significantly more prevalent in the chlorthalidone 50.0‐mg group than in the placebo group. The data suggest that most elderly patients with isolated systolic hypertension, regardless of the severity, could be treated effectively and safely with chlorthalidone 12.5 mg per day.