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Aging, Regional Cerebral Blood Flow, and Neuropsychological Functioning
Author(s) -
MacInnes William D.,
Golden Charles J.,
Gillen Robert W.,
Sawicki Robert F.,
Quaife Merton,
Uhl Henry S. M.,
Greenhouse Arnold J.
Publication year - 1984
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1984.tb04169.x
Subject(s) - cerebral blood flow , medicine , neuropsychology , cognition , psychiatry
Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. However, no study has yet demonstrated a relationship between rCBF and performance on the Luria‐Nebraska Neuropsychological Battery (LNNB) in an elderly group. Seventy‐nine elderly volunteers (56–88 years old), both healthy and demented, underwent the 133 xenon inhalation rCBF procedure and were given the LNNB. The decrements in the gray‐matter blood flow paralleled decrements in performance on the LNNB. Using partial correlations, a significant proportion of shared variance was observed between gray‐matter blood flow and the LNNB scales. However, there was much less of a relationship between white‐matter blood flow and performance on the LNNB. This study suggests that even within a restricted age sample rCBF is related in a global way to neuropsychological functioning.