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Adipocyte Hormone Responsiveness and Aging in the Rat: Problems in the Interpretation of Aging Research
Author(s) -
KIRKLAND JAMES L.,
DAX ELIZABETH M.
Publication year - 1984
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1984.tb02006.x
Subject(s) - hormone , medicine , adipocyte , endocrinology , mechanism (biology) , senescence , metabolism , adipose tissue , philosophy , epistemology
Fat is a metabolically dynamic tissue. Its metabolism is under the control of several well‐characterized hormonal systems. There appear to be changes in the hormonal sensitivity of rat fat with age. No single mechanism has been proved to explain all the changes observed in adipocyte hormonal responsiveness with aging, although it does seem likely that age does have an independent effect on fat metabolism from studies to date.