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Cardiovascular Effects of Caffeine in Elderly Men
Author(s) -
CONRAD KENNETH A.,
BLANCHARD JAMES,
TRANG JOHN M.
Publication year - 1982
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1982.tb07100.x
Subject(s) - caffeine , medicine , blood pressure , diastole , inotrope , cardiology , anesthesia
Ten healthy elderly male volunteers were given 4 mg/kg of caffeine by intravenous infusion on three separate occasions. This resulted in mean peak plasma concentrations of caffeine of 7.4 ± 0.7 μg/ml. Immediately after each of the three caffeine infusions, the mean systolic blood pressures increased 14, 7, and 16 mm Hg, and the mean diastolic blood pressures increased 7, 4, and 7 mm Hg, respectively. Both the systolic and the diastolic blood pressures returned to preinfusion values within 4 hours. The QS 2 index and the left ventricular ejection time (LVET) index increased after caffeine, probably as a result of the caffeine‐induced increase in arterial blood pressure. The pre‐ejection period (PEP), the PEP/LVET ratio, and the diastolic time remained unchanged. Caffeine, in doses equal to those contained in 2 to 3 cups of coffee, produces an increase in blood pressure but has no demonstrable positive inotropic effect in healthy elderly men.