Werner's Syndrome: Twenty‐four Cases with a Review of the Japanese Medical Literature

Twenty‐four cases of Werner's syndrome were studied to define the clinical manifestations in comparison with those found in a clinical review of 153 cases in the Japanese medical literature. The conspicuous characteristics of the 24 patients were short stature, stocky trunk with thin limbs, low body weight, bird‐like or “masked” face, early graying or loss of hair, high‐pitched or hoarse voice, bilateral cataracts, and various scleroderma‐like signs. Three signs not stressed previously were hyperreflexia, flat feet, and irregular dental development. The onsets and incidences of these manifestations during the seven‐year serial study are described.