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Chlorpropamide‐Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion
Author(s) -
TANAY A.,
FIREMANN Z.,
YUST I.,
ABRAMOV A. L.
Publication year - 1981
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1981.tb01277.x
Subject(s) - chlorpropamide , medicine , antidiuretic , diabetes mellitus , endocrinology , complication , hormone , pediatrics , syndrome of inappropriate antidiuretic hormone secretion
The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is a rare but serious complication of chlorpropamide therapy. In 2 elderly women who had diabetes mellitus, the SIADH developed two months after the chlorpropamide dosage had been increased to 500 mg daily. The syndrome disappeared after withdrawal of the drug. In one of these patients, re‐administration of chlorpropamide resulted in recurrence of the SIADH. A review of the current literature disclosed certain common denominators, i.e., most of the patients are elderly women whose dosage of chlorpropamide was increased shortly before the development of the SIADH.