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Serum Glucagon after Arginine Infusion in Aged and Young Subjects
Author(s) -
Ferrero Enrico,
Casale Giorgio,
De Nicola Pietro
Publication year - 1980
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1980.tb00537.x
Subject(s) - glucagon , medicine , endocrinology , arginine , insulin , hormone , diabetes mellitus , pancreatic hormone , growth hormone , insulin resistance , amino acid , biochemistry , chemistry
In 12 aged nondiabetic subjects, 10 aged diabetic subjects, and 6 young nondiabetic subjects the glucose, insulin, glucagon and growth hormone responses to the intravenous administration of arginine were studied. A prompt increase in the levels of blood glucose, serum insulin and serum glucagon was observed, but the glucose and glucagon peaks were significantly higher in the aged nondiabetic and diabetic subjects. Growth hormone secretion did not differ between the nondiabetic aged and young subjects. These findings suggest the hypothesis that glucose intolerance in old age is due to increased release of glucagon.