Premium
Changes in Hormonal Activities Relative to the Severity of Essential Hypertension
Author(s) -
ITO KAZUKI,
KUBOTA TETSUHIRO,
YAMADA TAKASHI,
TAWATA MASATO,
TSUKUI TOMOMICHI,
NAGATA HAJIME,
IZUMIYAMA TOMIO,
KONO SHIRO,
KAMATA KAZUO
Publication year - 1979
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1979.tb06030.x
Subject(s) - medicine , endocrinology , plasma renin activity , blood pressure , essential hypertension , norepinephrine , excretion , creatinine , renin–angiotensin system , kidney , urinary system , renal function , dopamine
Endocrine activity in patients with essential hypertension was studied by measuring the urinary excretion of catecholamines, prostaglandin E (PGE) and cyclic adenosine monophosphate (cAMP). Simultaneously, plasma renin activity, concentrations of serum sodium, potassium, blood urea nitrogen (BUN) and creatinine were determined. Systolic blood pressure and BUN increased progressively with age until the sixth decade. Urinary excretion of norepinephrine was correlated with the systolic blood pressure. In contrast, plasma renin activity and urinary excretion of PGE decreased progressively with the increase in systolic blood pressure. Although the cause of essential hypertension is not known, it is suggested that hypertension accelerates the aging process in the kidney and thus decreases renal PGE synthesis. This decrease of PGE in turn causes a reduction of plasma renin activity, possibly either by accelerating the retention of sodium and water or by failing to stimulate renin synthesis. A decrease of PGE may also potentiate the vasopressor action of norepinephrine.