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Centrophenoxine: Effects on Aging Mammalian Brain
Author(s) -
Nandy K.
Publication year - 1978
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1978.tb02544.x
Subject(s) - lipofuscin , hippocampus , medicine , autofluorescence , cerebral cortex , cortex (anatomy) , neuroscience , brain aging , endocrinology , physiology , pathology , biology , disease , physics , quantum mechanics , fluorescence
A study was made of the effects of centrophenoxine on the learning and memory of old mice. The results were correlated with changes in neuronal lipofuscin in the cerebral cortex and hippocampus. Old female mice (11–12 months) were treated with centrophenoxine for three months and their learning and memory were tested in a T‐maze. The number of trials required to attain the criterion in the 20 treated old mice were compared with those for 20 untreated mice of the same age and for 20 younger untreated mice. The treated animals learned the task with significantly fewer trials, and also exhibited a reduction of neuronal lipofuscin pigment in both the cerebral cortex and the hippocampus. The changes in lipofuscin were demonstrated by study of the characteristic autofluorescence, and by histochemical and ultrastructural (electron microscope) observations.