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Central Neurotransmitter Substances and Aging: A Review
Author(s) -
Samorajski T.
Publication year - 1977
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1977.tb00657.x
Subject(s) - neurotransmitter , medicine , neurotransmitter systems , neuroscience , neurotransmitter agents , stimulation , central nervous system , endocrinology , dopamine , biology
Available evidence suggests that age is an important determinant of the levels of neurotransmitters and their associated enzymes and metabolites in some regions of the brain. Alterations at the synaptic level, or selective cell death in the brain, or both, may be implicated in progressive loss of function, behavioral changes and the onset of age‐related diseases. Stimulation of hypothalamic neuroendocrine transducer cells by agents that alter neurotransmitter metabolism might provide some measure of control of the process of aging.