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A Device for Expressing the Serum Insulin‐Glucose Relationship in Diabetes, Hyper‐ or Hypothyroidism, and Chronic Hepatitis
Author(s) -
Yamada Takashi,
Ohtake Masao,
Kotani Masanobu
Publication year - 1977
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1977.tb00284.x
Subject(s) - medicine , insulin , diabetes mellitus , endocrinology , sulfonylurea , chronic hepatitis , glucose tolerance test , insulin resistance , immunology , virus
When the serum insulin values during a 50‐gm oral glucose tolerance test were expressed as the function of glucose concentrations, a good linear relationship was found in normal subjects and in patients with diabetes, hyperthyroidism, hypothyroidism or chronic hepatitis. The insulin index calculated from the line representing this relationship was less than 100 in all 19 diabetic patients and most of the 13 hyperthyroid patients with oxyhyperglycemia, whereas it was more than 100 in the 14 normal subjects, the 4 hypothyroid patients, and the 8 patients with oxyhyperglycemia due to chronic hepatitis. The insulin index decreased with increasing maximal blood glucose concentration during the glucose tolerance test in diabetic patients. Furthermore, improvement in the insulin index was correlated with the effectiveness of sulfonylurea drugs in the diabetic group.