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Tumor Immunology, Autoimmunity and Aging *
Author(s) -
YUNIS EDMOND J.,
FERNANDES GABRIEL,
GREENBERG LEONARD J.
Publication year - 1976
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1976.tb03301.x
Subject(s) - autoimmunity , immune system , medicine , immunology , malignancy , immunosenescence , immunologic function
Cell‐mediated immune function declines with aging, and may be associated with autoimmunity and malignancy. Humoral immune responses also decline with aging. The chief age‐related effect on the immune system is a decrease in T‐cell function. The “thymus clock” and immunogenesis are discussed in relation to aging. In animals, attempts at immunologic rejuvenation by cellular or hormonal means have not been as successful as the results attained by genetic manipulation.