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Effect of Normalization of Hypometabolic State on Blood Pressure in Spontaneously Hypertensive Rats and in Patients with Essential Hypertension *
Author(s) -
KOIZUMI YOICHI,
AIZAWA TORU,
TAWATA MASATO,
YAMADA TAKASHI,
YAMORI YUKIO,
OKAMOTO KOZO
Publication year - 1976
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1976.tb03259.x
Subject(s) - medicine , endocrinology , triiodothyronine , essential hypertension , hormone , blood pressure , thyroid , thyroid function
Spontaneously hypertensive rats (SHR) manifest a hypothyroid state as evidenced by increased thyroid weight, an increased level of plasma thyroid‐stimulating hormone (TSH) and a decreased level of plasma thyroxine (T 4 ) and triiodothyronine (T 3 ). In 18 patients with essential hypertension, plasma TSH, T 4 and T 3 concentrations were all within the normal range, but the T 4 level was significantly lower than in the controls. Among 21 hypothyroid patients, 2 had essential hypertension. Administration of thyroid hormone brought the metabolic state to normal in SHR and in hypothyroid patients but failed to affect the blood pressure. It is suggested that abnormality of thyroid function is neither the cause nor the accentuating factor in the development of hypertension in SH rats and in man.