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The Use of Urokinase in Acute Myocardial Infarction: Report of Two Cases †
Author(s) -
Mazel M. S.,
Parsa F.,
Riera R.
Publication year - 1975
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1975.tb00428.x
Subject(s) - medicine , urokinase , thrombolysis , myocardial infarction , cardiology , collateral circulation , blood flow , coronary occlusion , artery , occlusion , angiography
In the course of a study (now including 53 patients) on the effectiveness of urokinase in the treatment of acute coronary occlusion, coronary angiography was performed in 2 patients before and after the use of this drug. In both instances the angiograms demonstrated obstruction in the coronary‐artery branches, with additional narrowing and some collateral circulation. After urokinase therapy, blood flow was restored in the areas previously obstructed. These 2 case reports are presented because they demonstrate this favorable change in coronary blood flow in association with this particular form of therapy. It is hoped that the completed urokinase study may add some information concerning the effect of thrombolysis in the management of myocardial infarction.