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Visual Hallucinations and Delirium During Treatment with Amantadine (Symmetrel)
Author(s) -
Postma J. U.,
Van Tilburg W.
Publication year - 1975
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1975.tb00187.x
Subject(s) - amantadine , medicine , delirium , anticholinergic , visual hallucination , incidence (geometry) , complication , anesthesia , intensive care medicine , surgery , psychiatry , pharmacology , physics , optics
ABSTRACT In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy. The symptoms promptly disappeared when amantadine was discontinued. Thereafter, each parkinsonian patient was treated satisfactorily with levo‐dopa. Treatment with a combination of amantadine and an anticholinergic agent increases the likelihood of delirium because of the hazard of retention of urine. Although amantadine is effective in the treatment of Parkinson's disease in the elderly, the incidence of delirium as a complication seems higher in this age group.