Premium
Hemolytic and Conglutinating Complement in Normal and Pathologic Human Sera
Author(s) -
KALLIOMÄKI J. L.,
MUSTAKALLIO E.,
MUSTAKALLIOCOOK SOLE
Publication year - 1974
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1974.tb06271.x
Subject(s) - medicine , titer , erythrocyte sedimentation rate , myelofibrosis , immunology , rheumatoid arthritis , antibody , bone marrow
A simultaneous determination of the hemolytic (CH) and conglutinating complement (Cc) was made on 587 “healthy” sera [Blood Transfusion Service (BTS) material] and 1036 pathologic sera [hospital material]. Sex, blood group and erythrocyte sedimentation rate did not affect the titer distribution. Older subjects, however, tended to show higher titers than did the young. Both for CH and Cc, the titers in the hospital patients were distinctly higher than in the BTS subjects. In patients with glomerulonephritis, both the CH and Cc titers were decreased whereas in patients with systemic lupus erythematosus only the CH titers were low. In leukemia, both the CH and Cc titers were higher than normal; in myelofibrosis, only the CH titers. In rheumatoid arthritis, the distribution of CH titers did not differ from that in the general hospital material, whereas the Cc titers were elevated. According to a previous concept, the conglutinating complement involves C142 activity. On the basis of present findings, this concept should be re‐evaluated by means of modern methods, especially taking into account the role of immunoconglutinins in the functioning of the complement system. The method used in this study—simultaneous titration of CH and Cc in the same series of tubes—is well adapted to routine use.