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Antiviral Drugs in Jakob‐Creutzfeldt Disease
Author(s) -
HERISHANU Y.
Publication year - 1973
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1973.tb01676.x
Subject(s) - medicine , dysgraphia , myoclonic jerk , amantadine , idoxuridine , slow virus , disease , myoclonus , subacute sclerosing panencephalitis , pediatrics , audiology , virus , progressive multifocal leukoencephalopathy , virology , psychiatry , dyslexia , measles virus , measles , reading (process) , political science , law , vaccination
A 61‐year‐old patient had a rapidly progressive neurological syndrome consisting of aphasia, dysgraphia, dyslexia, right‐left disorientation, slight motor lateralizing signs, tremor and myoclonic jerks. The electroencephalogram showed the bursts of spikes and slow waves (1 per second) characteristic of Jakob‐Creutzfeldt disease (spastic pseudosclerosis). A Nevin‐Jones variant of the disease was diagnosed. Amantadine and idoxuridine were given without any positive effect. The patient died in a state of septicemia. A review of experience with antiviral drugs in slow virus neurological infections is presented.