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Long‐Term Results with Oral Hypoglycemic Drugs
Author(s) -
MOSS JAMES M.,
DeLAWTER DeWITT E.
Publication year - 1973
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/j.1532-5415.1973.tb01221.x
Subject(s) - medicine , longevity , phenformin , sulfonylurea , diabetes mellitus , insulin , disease , diabetes treatment , gerontology , type 2 diabetes , endocrinology , metformin
An analysis was made of the records of 1,840 patients in whom diabetes started after the age of 35 and before the age of 70, and who were under the authors' care for from one to fifteen years. According to the predictions of life‐insurance tables, these patients lived longer than non‐diabetic patients. There was a significant decrease in longevity in those who had persistent hyperglycemia. The greatest increase in longevity occurred in those whose disease could be controlled by diet alone or with sulfonylurea drugs. There was less apparent benefit from phenformin or insulin in this respect. In comparison, the findings of the University Group Diabetes Program are discussed in some detail. The authors' data indicate that, in the treatment of diabetes, sulfonylurea drugs have a beneficial effect upon longevity when they are used properly.